SASSETTI LAB

Baer CE, Iavarone AT, Alber T, Sassetti CM. Biochemical and Spatial Coincidence in the Provisional Ser/Thr Protein Kinase Interaction Network of Mycobacterium tuberculosis. J Biol Chem. 2014 Jun 13. pii: jbc.M114.559054. PubMed PMID: 24928517.

 

Raimunda D, Long JE, Padilla-Benavides T, Sassetti CM, Argüello JM. Differential roles for the Co(2+) /Ni(2+) transporting ATPases, CtpD and CtpJ, in Mycobacterium tuberculosis virulence. Mol Microbiol. 2014 Jan;91(1):185-97. doi: 10.1111/mmi.12454. Epub 2013 Nov 20. PubMed PMID: 24255990; PubMed Central PMCID: PMC3885230.

 

Rittershaus ES, Baek SH, Sassetti CM. The normalcy of dormancy: common themes in microbial quiescence. Cell Host Microbe. 2013 Jun 12;13(6):643-51. doi: 10.1016/j.chom.2013.05.012. Review. PubMed PMID: 23768489; PubMed Central PMCID: PMC3743100. 

 

O'Sullivan BP, Sassetti CM. Infection control in cystic fibrosis: share and share alike. Lancet. 2013 May 4;381(9877):1517-9. doi: 10.1016/S0140-6736(13)60740-0. Epub 2013 Mar 29. PubMed PMID: 23541536.

 

Padilla-Benavides T, Long JE, Raimunda D, Sassetti CM, Argüello JM. A novel P(1B)-type Mn2+-transporting ATPase is required for secreted protein metallation in mycobacteria. J Biol Chem. 2013 Apr 19;288(16):11334-47. doi: 10.1074/jbc.M112.448175. Epub 2013 Mar 12. PubMed PMID: 23482562; PubMed Central PMCID: PMC3630897.

 

DeJesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics. 2013 Mar 15;29(6):695-703. doi: 10.1093/bioinformatics/btt043. Epub 2013 Jan 29. PubMed PMID: 23361328; PubMed Central PMCID: PMC3597147.

 

Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β. Nat Immunol. 2013 Jan;14(1):52-60. doi: 10.1038/ni.2474. Epub 2012 Nov 18. PubMed PMID: 23160153; PubMed Central PMCID: PMC3721324.

 

Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JC. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One. 2013 Sep 23;8(9):e75245. doi: 10.1371/journal.pone.0075245. eCollection 2013. PubMed PMID: 24086479; PubMed Central PMCID: PMC3781026.

 

Shell SS, Prestwich EG, Baek SH, Shah RR, Sassetti CM, Dedon PC, Fortune SM. DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. PLoS Pathog. 2013;9(7):e1003419. doi: 10.1371/journal.ppat.1003419. Epub 2013 Jul 4. PubMed PMID: 23853579; PubMed Central PMCID: PMC3701705.

 

Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. PLoS Pathog. 2012 Sep;8(9):e1002946. doi: 10.1371/journal.ppat.1002946. Epub 2012 Sep 27. PubMed PMID: 23028335; PubMed Central PMCID: PMC3460630.

 

Lee HJ, Lang PT, Fortune SM, Sassetti CM, Alber T. Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis. Nat Struct Mol Biol. 2012 Aug;19(8):811-8. doi: 10.1038/nsmb.2318. Epub 2012 Jul 8. PubMed PMID: 22773105; PubMed Central PMCID: PMC3414669.

 

Raimunda D, Long JE, Sassetti CM, Argüello JM. Role in metal homeostasis of CtpD, a Co²⁺ transporting P(1B4)-ATPase of Mycobacterium smegmatis. Mol Microbiol. 2012 Jun;84(6):1139-49. doi: 10.1111/j.1365-2958.2012.08082.x. Epub 2012 May 17. PubMed PMID: 22591178; PubMed Central PMCID: PMC3370075.

 

Griffin JE, Pandey AK, Gilmore SA, Mizrahi V, McKinney JD, Bertozzi CR, Sassetti CM. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Chem Biol. 2012 Feb 24;19(2):218-27. doi: 10.1016/j.chembiol.2011.12.016. Erratum in: Chem Biol. 2012 Sep 21;19(9):1210. PubMed PMID: 22365605; PubMed Central PMCID: PMC3292763.

 

Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal. 2012 Jan 24;5(208):ra7. doi: 10.1126/scisignal.2002525. PubMed PMID: 22275220; PubMed Central PMCID: PMC3664666.

 

Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog. 2011 Sep;7(9):e1002251. doi: 10.1371/journal.ppat.1002251. Epub 2011 Sep 29. PubMed PMID: 21980284; PubMed Central PMCID: PMC3182942.

 

Baek SH, Li AH, Sassetti CM. Metabolic regulation of mycobacterial growth and antibiotic sensitivity. PLoS Biol. 2011 May;9(5):e1001065. doi: 10.1371/journal.pbio.1001065. Epub 2011 May 24. PubMed PMID: 21629732; PubMed Central PMCID: PMC3101192.

 

Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ. Depletion of antibiotic targets has widely varying effects on growth. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4176-81. doi: 10.1073/pnas.1018301108. Epub 2011 Feb 22. PubMed PMID: 21368134; PubMed Central PMCID: PMC3053961.

 

Sassetti CM, Rubin EJ. Relics of selection in the mycobacterial genome. Nat Genet. 2010 Jun;42(6):476-8. doi: 10.1038/ng0610-476. PubMed PMID: 20502489; PubMed Central PMCID: PMC4043303.

 

Murry JP, Pandey AK, Sassetti CM, Rubin EJ. Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity. J Infect Dis. 2009 Sep 1;200(5):774-82. doi: 10.1086/605128. PubMed PMID: 19622047; PubMed Central PMCID: PMC3677186.

 

Coulombe F, Divangahi M, Veyrier F, de Léséleuc L, Gleason JL, Yang Y, Kelliher MA, Pandey AK, Sassetti CM, Reed MB, Behr MA. Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med. 2009 Aug 3;206(8):1709-16. doi: 10.1084/jem.20081779. Epub 2009 Jul 6. PubMed PMID: 19581406; PubMed Central PMCID: PMC2722178.

 

Chang JC, Miner MD, Pandey AK, Gill WP, Harik NS, Sassetti CM, Sherman DR. igr Genes and Mycobacterium tuberculosis cholesterol metabolism. J Bacteriol. 2009 Aug;191(16):5232-9. doi: 10.1128/JB.00452-09. Epub 2009 Jun 19. PubMed PMID: 19542286; PubMed Central PMCID: PMC2725594.